The SCID-hu mouse model has facilitated a rigorous evaluation of the role of several VZV genes in vivo. For example, while previous in vitro studies have indicated that ORFs 14, 47, and 66 are dispensable for viral replication (putative glycoprotein C, protein kinase, and protein kinase, respectively [55]) [69,70,71,72], data from studies using the SCID-hu mouse model demonstrate that ORFs 47 and 66 are required for VZV replication in human T cells, and ORFs 47 and 14 are necessary for infection and replication in skin cells [73]. Here, WEE1 is linked to infection.