PRDX5 and bacterial infectious disease: Recently another ROS protection gene was shown to protect the host during intestinal bacterial infection in Drosophila. The JNK/FOXO pathway regulates the expression of the antioxidant enzyme Peroxiredoxin V (dPrxV) to protect intestinal epithelial cells from oxidative damage, as, for instance, dPrxV mutants exhibit increased lethality during bacterial infection [32].