Interestingly, decreased PTPN13 expression correlates with changes in cellular proliferation and invasive characteristics in multiple epithelial cells in vitro as well as in tumors in vivo. Taken together, these data suggest not only that PTPN13 is a tumor suppressor, but also that loss of PTPN13 expression or function affects mitosis [19-27]. The gene discussed is PTPN13; the disease is neoplasm.