To determine whether loss of LKB1 expression is responsible for enhanced breast cancer cell metabolism, we analyzed the presence of metabolites in whole LKB1−/−NIC mammary tumors compared to tumors harvested from NIC control mice and from wild-type (WT) mammary glands by NMR analysis (Chenomx Inc.)(Fig.1). The gene discussed is STK11; the disease is breast carcinoma.