We found that inhibition of mTOR with AZD8055, a novel ATP-competitive inhibitor of mTOR that inhibits both mTORC1 and mTORC2 [10], inhibited mTOR signaling and expression of glycolytic enzymes, lactate dehydrogenase (LDH) and pyruvate dehydrogenase (PDH), in primary breast cancer cells isolated from LKB1−/−NIC mice [9]. This evidence concerns the gene PDP1 and breast cancer.