CASP2 and breast adenocarcinoma: It has been demonstrated by using in vitro coimmunoprecipitation experiments that NALP1 (DEFCAP) protein is capable of strongly interacting with caspase-2, and transient overexpression of full-length DEFCAP-L, but not DEFCAP-S, in breast adenocarcinoma cells MCF-7 resulted in significant levels of apoptosis [23].