After treatment with both albendazole (an antihelmintic) and doxycycline (used in this study as a non-selective MMP inhibitor), a significant reduction of the levels of MMP-12, elastin and Evans blue accumulation in the CSF in mice with meningitis was observed, suggesting that MMP-12 contributes to elastin degradation, which is reduced by the action of doxycycline on the inflammatory reaction mediated by MMP-12 [145]. The gene discussed is ELN; the disease is meningitis.