brucei-infected mice, a massive increase in parasite and leukocyte numbers was accompanied by a significantly induced mRNA expression of MMP-3, MMP-8 and MMP-12, at thirty days post-infection, whereas levels of MMP-1b, -2, -7, -9, -11, -13, -14 and -19 and TIMP-1 and -2 mRNA were unaltered and MMP-10 was undetectable [120]. This evidence concerns the gene TIMP1 and infection.