MUC2 and infection: In Citrobacter rodentium infection [mouse model of Enteropathogenic E. coli (EPEC) and Enterohemorrhagic E. coli (EHEC)], it has been shown that Muc2 production plays a critical role in host protection by limiting overall pathogen and commensal numbers, suggesting that Muc2-dependent mucus production is critical for effective management of both pathogenic and non-pathogenic bacteria during infection by an EPEC/EHEC-like pathogen [70].