For example, RIZ1, the full-length product of PRDM2, is a tumour suppressor protein because it demonstrates a loss of function in many types of human cancers with genomic deletions or point mutations and because RIZ1-deficient mice have been shown to develop diffuse large B cell lymphomas (DLBCL) [5,6,7]. The gene discussed is PRDM2; the disease is neoplasm.