TP53 and esophageal squamous cell carcinoma: As shown in Figure 2, the mutation was preferentially located in the Pro72 allele (p = 0.0001) (Table 2), thus supporting the result obtained for samples homozygous for codon 72 and enabling us to compare Pro72Arg polymorphism and p53 mutation status for all 75 ESCC samples which revealed that mutation was significantly associated with Pro72 allele (p = 0.0018) (Table 2).