EBV infection of GC B cells, the presumptive progenitors of the Reed Sternberg cells found in HL, was followed by the up-regulation of the protein arginine methyltransferases CARM1, PRMT1 and PRMT5, and by the down-regulation of the deiminase, PADI4. This evidence concerns the gene PADI4 and Epstein-Barr virus infection.