TP53 and neoplasm: Sivachandran et al. speculated that a decreased apoptotic response and impaired DNA repair associated with the downregulation of p53 levels by EBNA1 [7] as well as impaired acetylation of p53 due to the disruption of promyelocytic leukemia nuclear bodies (PML NBs) by EBNA1 also contribute to the development of EBV-associated neoplasms [8,9].