DDIT3 and cancer: These results have potential practical implications in the following aspects: (a) they suggest that this additive effect could be exploited to target the low bioavailability of RSV [53], [54] because it is possible to promote a RSV-associated toxicity in cancer cells when the transformed cells are also exposed to a richly saturated FA environment, and (b) they highlight that RSV-mediated inhibition of lipogenesis in a saturated fatty acid context could represent a promising anticancer therapy by inducing cell death through ER stress and CHOP activation.