It has been recently demonstrated that a granulocytic subtype (CD15+CD14−CD33+CD11b+) of MDSCs has suppressive activity, whereas an increased number of MDSCs (CD11b+CD14− cells) was negatively associated with the frequency of CD8+ T lymphocytes and responsiveness to treatment in patients with NSCLC [23]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.