BCL11B was first associated with hematological malignancies due to its recurrent involvement along with the homeobox transcription factor TLX3 (previously HOX11L2) in a significant percentage of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases carrying the cryptic t (5; 14) (q35; q32) [9]. Here, TLX3 is linked to acute lymphoblastic leukemia.