KLK5 and cancer: Associations of the clinically established variables of FIGO stage, nuclear grade, nodal status and ascitic fluid volume, with cancer biomarkers KLK5–7 KLK13, serum biomarker cancer antigen (CA)-125 and the OVSCORE were quantified employing the Mann-Whitney U test (Fig. 2): KLK5, KLK7 and the OVSCORE (as well as CA-125 in serum, data not shown) were associated with advanced FIGO stage (FIGO III/IV), higher nuclear grade (G3) and positive nodal status (N+); KLK13 was associated with nodal status (data not shown), while KLK6 was not significantly associated with these clinical factors.