As reported previously (8), in order to predict surgical success, we have developed the OVSCORE algorithm on the basis of a logistic regression model involving two clinical factors and two tumor biological factors, namely ascitic fluid volume and nuclear grading, and kallikrein-related peptidases (KLKs), KLK6 and KLK13, which are members of a serine protease family and are known to be associated with ovarian cancer progression and metastasis (9,10). The gene discussed is KLK6; the disease is ovarian cancer.