Considering the interaction between squamous cell carcinoma and myoepithelial cells under the influence of the tumor microenvironment (10), the present in vitro study aimed to examine the role of tumor-conditioned medium, obtained from melanoma and breast ductal adenocarcinoma cells, in the morphological and phenotypic alterations of neoplastic benign myoepithelial cells obtained from PA under a fibronectin substratum. This evidence concerns the gene FN1 and squamous cell carcinoma.