In the colorectal cancer samples, the differentiated-type tumors (including papillary, and well- and moderately-differentiated adenocarcinomas), based on histopathological grade, were significantly more likely to be DOK2(−) than DOK2(+) [DOK2(−), 69.7%; DOK2(+), 30.3%; P=0.001]. Here, DOK2 is linked to colorectal cancer.