CCN2 and Nephroblastoma: Wnt-1 inducible signaling pathway protein-2 (WISP-2), also known as CCN5, is a 29-kDa secreted protein that is a member of the connective tissue growth factor (CTGF) and nephroblastoma over-expressed gene family of matricellular proteins, and is critical in growth factor mediated cell proliferation (12–14).