CK8 and CK18 expression increased from 6.07±0.32 to 89.36±9.08% (P<0.01) and 2.71±0.18 to 98.64±10.13% (P<0.01), respectively, following cell adherence and tumor sphere differentiation in the culture system supplemented with 10% FBS. This evidence concerns the gene KRT8 and neoplasm.