TDP-43 pathology often but not invariably restricted to the amygdala and granule cell layer of the dentate gyrus and entorhinal cortex is present in up to 57% [11,13-15], and recently Josephs and colleagues [15] demonstrated that TDP-43 is an important factor in the manifestation of clinico-imaging features of AD. This evidence concerns the gene TARDBP and Alzheimer disease.