TARDBP and Alzheimer disease: Alzheimer’s disease (AD) in particular often presents with comorbid processes, including cerebrovascular disease, Lewy body (LB) pathology, argyrophilic grain disease, transactivation response DNA binding protein 43 kDa (TDP-43) pathology, and hippocampal sclerosis, and about two-thirds of aged human brains contain substantial non-AD pathology [9-11].