MAPT and Alzheimer disease: Indeed, in AD that is neuropathologically characterized by amyloid-beta (Aβ) and tau pathology (hyperphosphorylated tau), LB pathology (α-synuclein) is present in up to 43% [1,12] (AD with LBs restricted to the amygdala is considered a distinct form of α-synucleinopathy [12]) and severe cerebrovascular lesions are observed in up to 20% [2] of cases, respectively.