Moreover, they found that specific tocotrienols increase ERb translocation into the nucleus which, in turn, activates the expression of estrogen responsive genes (MIC-1, EGR-1 and Cathepsin D) in breast cancer cells only expressing ERb cells (MDA-MB- 231) and in cells expressing both ER isoforms (MCF-7). Here, ESR2 is linked to breast carcinoma.