As shown in Figure 5, treatments with SGD (10 and 20 mg/mL), paeoniflorin (0.25 and 0.5 mg/mL), and liquiritin (0.25 and 0.5 mg/mL) significantly decreased the mRNA levels of ER-α (0.000390 ± 0.000099, P < 0.01; 0.000136 ± 0.000051, P < 0.01; 0.006342 ± 0.000343, P < 0.01; 0.001910 ± 0.000704, P < 0.01; 0.013642 ± 0.003817, P < 0.01; 0.005028 ± 0.000456, P < 0.01), in comparison to control group (0.353722 ± 0.060531). Here, ESR1 is linked to specific granule deficiency.