In addition, a near research revealed that the mitochondria fission/fusion modulator-dynamin-related protein 1 (Drp1) plays an important role in promoting hyperglycemia-induced apoptosis of β-cells, while rhein reversed the expression of Drp1 and then largely localized at mitochondria in the β-cells and strongly protected pancreatic β-cells from hyperglycemia-induced apoptosis [21]. Here, DNM1L is linked to Hyperglycemia.