Rhein was also found to inhibit peroxisome proliferator-activated receptor gamma (PPARγ) signaling [19] and suppress the expression of sterol regulatory element-binding protein-1c (SREBP-1c) [20], leading to blocking high-fat diet-induced obesity and decreasing fat mass and lower serum cholesterol and LDL cholesterol in the mice, and ameliorating lipid metabolism. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.