PPARG and Obesity: Rhein was also found to inhibit peroxisome proliferator-activated receptor gamma (PPARγ) signaling [19] and suppress the expression of sterol regulatory element-binding protein-1c (SREBP-1c) [20], leading to blocking high-fat diet-induced obesity and decreasing fat mass and lower serum cholesterol and LDL cholesterol in the mice, and ameliorating lipid metabolism.