ERBB2 and neoplasm: Thirty-three and 30% of patients had node negative disease in HERA and BCIRG 006 study, respectively.9,10 On the contrary, in the Dutch cohort of 479 HER2 positive BC patients 55% had node positive disease.21 The aggressiveness of this type of BC could be reflected by larger volume of the disease at the first presentation and higher tumour grade.