The tumor-suppressive property of miR-134 was confirmed when overexpression of miR-134 inhibited proliferation in GBM cells and tumor growth in GSC-derived xenografts by targeting KRAS and STAT5B. MiR-134 regulation by RTK was mediated by MAPK and KLF4 transcription factor [11]. The gene discussed is KLF4; the disease is neoplasm.