Antimicrobial peptides, such as human β–defensins-2 (hBD-2), are crucial for host defense at mucosal surfaces while chemokines, such as interleukin-8 (IL-8), recruit neutrophils from the circulation into the subepithelial region to defend against the invasion of bacteria, but give rise to characteristic pathology of colitis [8]. This evidence concerns the gene CXCL8 and colitis.