ZEB factors and E12/E47 have been confirmed as promoters of EMT and metastasis, Snail and Slug (them all implicated in tumor development) firmly have the roles in promoting EMT in tubular cells, in the fibrotic kidney and in human tumor cells [54-56], and Brachyury in human tumor cells [32].This observation leads us to speculate that Snail, Slug and Brachyury expression are correlated with EMT in HK-2 cells. Here, ZEB1 is linked to neoplasm.