As shown in Figure 6A, strong staining of Brachyury/Snail/Slug was observed in the nuclei of renal tubular epithelial cells and reduced expression of E-cadherin in IgA nephropathy patients with tubulointerstitial fibrosis, and the positive rate of three transcription factors was 74.4% (32/43), 48.8% (21/43) and 55.8% (24/43) respectively. Here, SNAI2 is linked to IgA glomerulonephritis.