Recent studies have shown that Brachyury promotes EMT involved in cancer progression and metastasis by repression of E-cadherin transcription, leading to a loss of E-cadherin-mediated cell–cell adhesion; thus, activation of EMT regulators might play important roles in mediating the invasion, migration, and metastatic activity of different carcinoma cells [32,33]. The gene discussed is TBX1; the disease is cancer.