Most recently, a transcription factor involved in epithelial–mesenchymal transition [62; for review 63, 64], ZEB2 (zing finger E-box binding protein 2) has been shown to activate MITF expression, and a ZEB2 loss that resulted in a decreased MITF level and several MITF-dependent target genes was associated with melanoma progression [65]. Here, ZEB2 is linked to melanoma.