The results of immunohistochemistry and western blot analyses indicated that the expression of Orai1, the key component of SOCE, is significantly correlated with the WHO grading of gliomas, with very low Orai1 expression in non-neoplastic brain tissues and very high Orai1 expression in glioblastoma samples and five glioma cell lines. This evidence concerns the gene ORAI1 and central nervous system cancer.