ORAI1 and central nervous system cancer: Compared with non-neoplastic brain tissues, low-grade gliomas (WHO II, n = 13) displayed slightly elevated Orai1 protein expression, whereas high-grade gliomas (WHO III, n = 12; WHO IV, n = 36) showed a significantly elevated Orai1 expression compared with non-neoplastic brain tissues and low-grade samples (Figure 1B).