In this study, we confirm the data published in our previous report showing that IDH1 mutations occur in ∼50 % of solitary conventional central chondrosarcomas, that the IDH1 mutations are found in all grades of this subtype of chondrosarcoma, that the R132C mutation is the most common genetic alteration in this gene, that IDH2 mutations are significantly less common than IDH1 mutations and that to date an IDH2 R140 mutation, which is seen in acute myeloid leukaemia, is not found in cartilaginous tumours [1]. The gene discussed is IDH1; the disease is acute myeloid leukemia.