Furthermore, we subsequently revealed that homozygous p16/CDKN2A deletions were only detected in high grade chondrosarcomas (GII, GIII and dedifferentiated) but not in GI central tumours, and that these genetics alterations were detected in both IDH1 mutant and wild-type (WT) central chondrosarcomas [12]. This evidence concerns the gene IDH1 and neoplasm.