E2F4 and colorectal carcinoma: According to the qRT-PCR results, PCOS CRC samples showed significant up-regulation of HIST1H4C (FC = 2.7, 95% HDI 0.436-4.49), UBE2C (FC (Fold Change) = 2.6, 95% HDI 0.00438-3.21) and E2F4 (FC = 2.5, 95% HDI 0.571-5.33).