De Nardo et al. showed experimental and clinical data consistent with this paradigm in breast cancer [38], although their analysis of the CD68/CD8 profile as a predictor of pCR was based on fine-needle aspiration (FNA) samples, in which stroma and immune-related stromal components are usually underrepresented in comparison with the core biopsy samples obtained from patients in our series [43]. Here, CD8A is linked to breast cancer.