Logistic regression multivariate models including tumor subtype and histological grade confirmed the independent predictive value of a higher pre-NCT CD3, CD4 and CD20 TIL subpopulations for pCR: CD3 (P = 0.007; OR = 11.7, 95%CI:1.97 to 69.2); CD4 (P = 0.005; OR = 11.0, 95% CI:2.0 to 59.7); and CD20 (P = 0.005; OR = 15.3, 95% CI:2.2 to 104.1). Here, CD4 is linked to neoplasm.