This tumor subtype-independent association between pCR and a higher effect of chemotherapy on tumor infiltration was also found for two particular lymphocyte subpopulations: CD4 (P = 0.001; OR = 15.02, 95% CI: 2.89 to 77.92) and CD20 (P = 0.002; OR = 11.87, 95% CI: 2.47 to 57.01) (Additional file 2: Table S6). This evidence concerns the gene CD4 and neoplasm.