The aim of this study was to integrate the predictive and prognostic information obtained from the multiple immune cell populations of breast cancer (CD4, CD8, Foxp3, CD20, CD68), both in the pre-treatment and post-chemotherapy residual tumor setting, and to determine the changes induced by anthracycline and taxane NCT on TIL subpopulations. This evidence concerns the gene CD4 and breast carcinoma.