TLR4 and neoplasm: In addition, we demonstrated that inhibition of TLR-4 signal transduction and its downstream signaling by CLI-095 inhibited killing of 4T1 tumor cells by the mixture of purified BM-DC and NK cells activated by Immunomax® in vitro, reversing it to the level exhibited in NK/BM-DC co-culture before the addition of Immunomax® (Figure 5E).