This increase was suspected to be driven by overproduction of VLDL particles in HU particularly in Europeans (as evidenced by a significantly higher VLDL apo B to total apo B ratio in HU and gout; Table 2) and additionally by the Tg-enrichment of existing VLDL particles (a significantly higher VLDL Tg to VLDL apo B ratio in gout; Table 2) in the Polynesian participants only. This evidence concerns the gene APOB and gout.