APOB and gout: The genetic data are consistent with our association of reduced total apo B levels with HU and lead to the prediction that the urate-increasing A1CF allele would functionally associate with reduced apo B. Collectively these data raise the possibility that reduced apo B is a risk factor for HU, yet increased VLDL Tg (with a single apo B molecule per VLDL particle) could be involved in gout in the presence of HU.