MAPT and Alzheimer disease: Pre-neurofibrillary tangles are comprised in part, by pThr231 tau, while extracellular and intracellular neurofibrillary tangles (comprised of mostly filamentous tau) are stained with antibodies that recognize phosphorylation at sites Ser202/Thr205 (AT8) and Thr212/Ser214 (AT100) in Alzheimer’s disease [76].