Furthermore, we have recently shown that simvastatin is able to induce a decrease in cell proliferation and a significant increase of apoptosis in human NSCLC cell cultures [13], as well as to modulate Ras, MMP-2/9 and NF-κB activity in pulmonary neoplastic tissues obtained from patients undergoing therapeutic surgery for lung cancer [14]. This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.