TF and glioblastoma: In order to evaluate the in vitro cytotoxic effects of different NPs-ZOL formulations in comparison to the standard antineoplastic drugs, TMZ and FTM, on U373MG-LUC GBM cells, we treated the cells with increasing concentrations of free ZOL, NPs-ZOL, NPs-ZOL-Tf, TMZ and FTM for 72h.