RNF2 and familial pancreatic carcinoma: Here, we demonstrated that high H2AK119Ub1 expression combined with low H3K27Me3 expression in a tumor predicted a poorer prognosis and that elevated Ring1B combined with upregulated EZH2 was associated with a shorter survival time of pancreatic cancer patients, especially for those who were unable to be distinguished by the TNM staging system.