It has been previously reported that Bim was also critical for apoptosis following KIT inhibition by imatinib in GIST [28], BRAF V600E inhibition by imatinib in melanoma [37-39] and EGFR inhibition by gefitinib in non-small cell lung cancers [29,40-42]. This evidence concerns the gene BCL2L11 and gastrointestinal stromal tumor.