Furthermore, the main proteins responsible for G2/M cell cycle transition, such as Aurora A, B, cdc2, and Cdc25C, were down-regulated under NSC745885 treatment in MBT2 and T24 bladder cancer cells, but not in SV-HUC-1 immortalized normal urothelial cells (Supplemental Fig. 4). This evidence concerns the gene CDC25C and urinary bladder cancer.