Moreover, NSC745885 and doxorubicin both decreased EZH2 protein levels in drug-sensitive MGH-U1 bladder cancer cells, but only NSC745885, not doxorubicin, down-regulated EZH2 expression in multi-drug-resistant MGH-U1R bladder cancer cells (Fig. 3B). This evidence concerns the gene EZH2 and urinary bladder carcinoma.