After obtained KIF18A expression results, we performed statistical analysis to determine the relevance between KIF18A and clinical pathological data (Table 1), and found that KIF18A expression was correlated with serum AFP level (≥200 ng/ml) (χ2 = 4.684, P = 0.030), tumor size (≥5cm) (χ2 = 6.787, P = 0.009), clinical TNM stage (χ2 = 14.312, P <0.001) and PVTT (χ2 = 7.228, P = 0.007), but was not obviously related to age, gender, family history, HBsAg, liver cirrhosis, distant metastasis, or postoperative recurrence (all P >0.05). Here, AFP is linked to cirrhosis of liver.