On the other hand, the close association of IL-17A G-197A (rs227593) gene SNP with susceptibility to the development of osteoarthritis (OA) in the Korea population has been described; however, they did not find relationship between the IL-17F A7488G (His161Arg, rs763780) gene SNP and OA susceptibility [20]. Here, IL17A is linked to osteoarthritis.