NFKB1 and aneurysm: From the above study, we speculated that the complex signaling pathway including MAPK and NF-κB, the crosstalk between oxidative stress, and inflammation may be more important factor in the pathogenesis of aneurysms; the effect of curcumin on the treatment of aneurysm may be multiple-targeted including its anti-inflammatory and antioxidant effects by inhibition of multiple signaling pathways, including MAPK and NF-κB signaling pathway.