ENG and pituitary gland adenoma: In addition, the combination of different types of immunostaining techniques such as CD105 (Endoglin) [28, 29] and Endocan [30] for the detection of microvessels in pituitary adenomas by using fractal analysis is an objective computer-aided technique for quantifying and describing the morphological aspects of microvessels that has potential implications in future clinical and surgical applications [2].