Single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in the human CR1 gene were found to be highly associated with late onset AD in a number of studies and across ethnic groups (Bertram et al., 2007; Lambert et al., 2009; Biffi et al., 2010, 2012; Carrasquillo et al., 2010; Chibnik et al., 2011; Brouwers et al., 2012; Crehan et al., 2012; Hazrati et al., 2012; Keenan et al., 2012; Ma et al., 2014). The gene discussed is CR1; the disease is Alzheimer disease.