For comparison with cellular markers that are characteristic of human GBM (Motomura et al., 2012; TCGA, 2008), we examined the level and distribution of GFAP, Nestin, Sox-2 and Olig-2 in GBM from TRP mice by immunohistochemistry (IHC) (supplementary material Fig. S1B,C). Here, SOX2 is linked to glioblastoma.