SOX2 and neoplasm: The distribution of the neural progenitor markers Nestin and Sox-2 (supplementary material Fig. S1C) aligned with other models in that Nestin expression was cytoplasmic and mainly in the tumor periphery, whereas Sox-2 was expressed in the nucleus by the majority of proliferative cells (Alcantara Llaguno et al., 2009; Kwon et al., 2008; Prestegarden et al., 2010).