IHC staining was used to analyze the relationship between the expression of OTUB1 and E-cadherin, β-catenin, and vimentin in 40 CRC tissues; representative images are shown in Figure 4A. E-cadherin expression was negatively correlated with OTUB1 expression (Figure 4B (i), r = -0.512, P =0.001). Here, OTUB1 is linked to colorectal carcinoma.