Other important clinical features, which are not included in the POEMS acronym, include papilledema, thrombocytosis/erythrocytosis, elevated vascular endothelial growth factor (VEGF) levels, and extravascular volume overload such as peripheral edema, ascites, pleural effusion, and pericardial effusion [6-9]. The gene discussed is VEGFA; the disease is thrombocytosis disease.