Although RVs cause a limited replicative infection in human monocytes/MØs in vitro, RV replication modulates surface costimulatory molecule expression and soluble mediators such as IL-10 and cytokine and chemokine production (TNF-α, IL-8/CXCL8, monocyte chemo-attractant protein-1/CCL2, IFN-γ-inducible protein 10 (IP-10)/CXCL10, IL-12, IL-15) and type I and III IFN production [134–145]. This evidence concerns the gene IL10 and infection.