During respiratory viral infections (influenza, respiratory syncytial virus, and rhinoviruses (RVs)), animal models suggest that early upregulated IL-10 levels at the beginning of a viral infection can be correlated with high virus infiltration, while the presence of IL-10 later on during the viral infection may prove beneficial and may play an important role in resolving the inflammatory responses [104]. The gene discussed is IL10; the disease is viral infectious disease.