This polymorphism leads to a histidine to arginine (H to R) substitution within FCGR2A that decreases the affinity of the receptor for human immunoglobulin G. When 23 EBV-positive and 81 EBV-negative HL cases were compared, 87% of EBV-positive cases carried at least one arginine-encoding allele compared with 68% of EBV-negative HL (p = 0.06); this gene has not been associated with HL by GWAS, although larger candidate genes studies have associated it with lymphoma risk [79]. The gene discussed is FCGR2A; the disease is Hodgkins lymphoma.